Patricia Arquette honored her late sister Alexis and championed trans rights during her Emmys speech

Actress Patricia Arquette opened up about her late sister Alexis and championed trans rights in her acceptance speech during the 2019 Emmy awards, which took place at LA's Microsoft theater on Sunday.

"I lost my sister Alexis, and trans people are still being persecuted, and I'm in mourning every day of my life," Arquette said during her moving speech for the best lead actress in a limited series or movie win. The actress earned her Emmy award for playing Dee Dee Blanchard on Hulu's "The Act."

"I'm in mourning, Alexis," she continued, "and I will be the rest of my life until we change the world, until trans people are not persecuted."

Read more: Here are all the 2019 Emmy winners

Arquette also urged potential employers to give jobs to trans people.

"Give them jobs, they're human beings, let's give them jobs," she said, adding, "Let's get rid of this bias we have everywhere."

Arquette's sister Alexis was a transgender actress and activist who appeared in films like "Pulp Fiction," "Bride of Chucky," and "The Wedding Singer," although she turned down roles that she felt played into demeaning transgender stereotypes. She died in 2016 at the age of 47 of HIV-related complications.

Arquette's speech elicited lots of cheers and applause from the audience, and "Orange Is the New Black" star Laverne Cox even stood up in support. Cox also held up her clutch, which was rainbow and featured a reference to two Title VII sexual orientation discrimination cases that are heading to the Supreme Court on October 8.

Chase Strangio, an attorney for the American Civil Liberties Union, accompanied "Orange Is the New Black" actress Laverne Cox to the 2019 Emmys.

Other winners from the night included Phoebe Waller-Bridge, Jason Bateman, Billy Porter, and Peter Dinklage, with Amazon's "Fleabag" and "The Marvelous Mrs. Maisel" taking home several awards.